Introduction Acne vulgaris is an ongoing, multifactorial inflammatory disorder of the pilosebaceous unit, predominantly impacting teenagers and young adults, however it may continue into later life stages [1]. It is clinically defined by a range of lesions, encompassing open and closed comedones, inflammatory papules, pustules, nodules, and cysts, primarily located on the face, chest, and back. Acne, with a global incidence affecting approximately 80–90% of teenagers, constitutes a major public health issue and significantly contributes to dermatological morbidity globally [2]. The pathophysiology of acne vulgaris is intricate and encompasses four principal processes: heightened sebum production induced by androgens, aberrant follicular keratinization resulting in comedone formation, colonization of the pilosebaceous unit by Cuti bacterium acnes, and ensuing inflammatory responses facilitated by both innate and adaptive immune mechanisms [3]. Recent advancements have underscored the significance of genetic predisposition, hormonal variations, and modifications in the skin microbiome in affecting disease susceptibility and severity [4]. Moreover, recent evidence indicates that systemic variables, like insulin resistance and high glycemic load diets, may intensify acne via hormonal and inflammatory mechanisms. Alongside biological variables, lifestyle and environmental factors have garnered heightened focus in recent years [5]. Psychological stress has been demonstrated to aggravate acne through neuroendocrine pathways, specifically via the hypothalamic–pituitary–adrenal (HPA) axis, which can elevate sebum production and inflammatory reactions [6]. Likewise, dietary patterns—particularly elevated consumption of dairy products, fast foods, and high-glycemic-index diets—have been correlated with acne severity in numerous epidemiological studies. Sleep deprivation, sedentary behavior, and improper cosmetic application exacerbate acne, especially in university students who frequently endure erratic schedules and academic pressure [7]. Aside from its physical manifestations, acne vulgaris has significant psychosocial consequences. It has been persistently linked to diminished self-esteem, social withdrawal, anxiety, and depression, consequently substantially reducing quality of life. The psychological impact of acne can, in certain instances, be akin to that of chronic systemic diseases, highlighting the necessity for holistic management strategies that encompass both physical and mental health dimensions [8]. Despite the wide global literature on acne, there is a scarcity of region-specific data in developing nations, like Pakistan, where social, nutritional, and environmental factors may significantly differ from those in Western populations. University students constitute a notably susceptible demographic owing to heightened stress exposure, nutritional inconsistencies, and lifestyle alterations [9]. Nevertheless, few research have investigated the synergistic impact of these modifiable risk variables within this demographic. This study is to evaluate the prevalence of acne vulgaris and determine its associated lifestyle and behavioral risk factors among university students. This study aims to enhance the existing knowledge base by offering localized evidence and to aid in the formulation of tailored preventative strategies and educational interventions to alleviate the prevalence of acne among young adults. Methodology Study Design and Setting A cross-sectional analytical investigation was performed during three months (January to March 2026) at a university campus in Pakistan. The study aimed to evaluate the prevalence of acne vulgaris and identify related lifestyle risk factors among university students. Study Population and Sampling The study population consisted of undergraduate and postgraduate students aged 18 to 30 years. A sample size of 250 individuals was determined utilizing standard prevalence estimation techniques, with a confidence level of 95%, a margin of error of 5%, and an anticipated prevalence of 50% owing to insufficient prior regional data. Participants were selected through a non-probability convenience sampling method from several academic fields. Inclusion and Exclusion Criteria Participants aged 18 to 30 years who consented to participate were included in the study. Individuals with chronic dermatological problems excluding acne (e.g., eczema, psoriasis), those undergoing systemic treatment for acne (e.g., isotretinoin, oral antibiotics), and those with recognized endocrine abnormalities impacting skin health were excluded to prevent confounding effects. Data Collection Procedure Data were gathered with a standardized, self-administered questionnaire created following an extensive examination of pertinent literature. The questionnaire comprised several sections, encompassing demographic variables (age, gender, academic year), lifestyle